Depot Testosterone is the first long-acting testosterone to be introduced to the market. It’s primary objective is the treatment of male hypogonadism. This is a condition where there is a reduced or absent secretion of testosterone from the testes. Decreased sex drive, erectile dysfunction, muscle loss and weakness and depression are all associated with hypogonadism. There is also an increased risk of developing osteoporosis.

Depot Testosterone is currently available under the brand name NEBIDO. It is designed to be injected every three months. Nebido contains Testosterone Undecanoate as its active ingredient. You may be familiar with this compound as it is also used in the oral steroid Andriol.

Nebido is injected slowly into the gluteal muscle, where it forms a reservoir of the drug. The compound then gradually releases from the injection site and is cleaved by serum esterases into testosterone and undecanoic acid.
On administration of Nebido serum concentrations of testosterone rapidly increase with notable elevations observed the very next day after injection.

This form of testosterone is also well-tolerated, local irritation being moderate and lasting for no more than three days. Another bonus with this form of testosterone is the fact that – unlike short acting esters- fluctuations in androgen levels are unlikely to be a problem. Hemoglobin and Hematocrit levels – although elevated – remain within the normal range and bone density shows a marked improvement.

THE BENEFITS

So, now you know the (condensed) science behind the product, what are its possible applications in the bodybuilding world?

Well, for a start there is the benefit of less frequent injections. There is also the convenience of steady serum testosterone levels. Depot testosterone (Nebido) also appears to have less influence on blood pressure and a lower tendency towards estrogen conversion. It also seems to have a favorable influence on cholesterol levels with studies reporting a slight decline in total cholesterol in patients who were given this substance.

DOSAGES

In medical trials, hypogonadal men were given an initial injection of 750mg Nebido, followed 4 weeks later by an additional 750mg ‘loading’ injection and then 750mg every 10 weeks thereafter. For bodybuilding purposes, there have been reports of competitors injecting anything from 1000 – 3000mg. This would lead to a sustained level of testosterone in the body lasting 10-12 weeks. On top of the testosterone they may add anabolic agents like Deca Durabolin, Equipoise or Trenbolone Acetate.

Nebido is distributed in multi-use vials, each containing 1000mg testosterone Undecanoate in a 4-ml solution for injection (250mg testosterone Undecanoate/ml).

N.B. Nebido is still relatively hard to find in comparison to the other testosterone esters. However, it is currently available from Maxi Medicine and you can find it at www.maximedicine.com

Leigh Penman, in addition to be a staff writer at MuscleSport Mag, has been writing for bodybuilding magazines, websites and nutritional supplement companies since 1985. Whilst residing in the UK, she earned the reputation of being one of the top female writers in bodybuilding-related media. Her credits included being a contributing editor on all the magazines in production as well as filling the shoes of Ladies Editor and Showbiz Editor on two publications (the later being on Arnold’s sanctioned magazine, ‘Bodypower’). During this time she also competed successfully on four occasions (placing in the top four in all contests).

Relocating to New York in the late 1990s she focused her writing attention to crystal healing techniques and metaphysics – however, she still maintained a five day workout schedule during this time and gained her personal training certificate.

Having also studied pharmacology in relation to sports performance, her writing began taking her in that direction until the present day which sees her embarking on a return to the magazine world, as well as extending her web-related work in the bodybuilding and fitness field.

Leigh has been working out for close to thirty years so she is clearly a writer who ‘walks her talk.’
She can be contacted personally at zeal2heal@yahoo.com.

This is part of a continuing series provided exclusively by MuscleSport Mag giving information on a variety of performance-enhancing drugs for educational purposes. While it is apparent that people are going to use these substances regardless of the health and legal risks involved, quality information is necessary and learning as much about them as possible can only assist an adult making a decision either way.

Testosterone Enanthate is an oil based injectable steroid, which is designed to slowly release testosterone from the injection site. This slow release delivery leads to an elevation in testosterone levels lasting for approximately two weeks (it may even take as long as three weeks for the drug levels to fully diminish). Due to its relatively long activity level, Testosterone Enanthate is favored by the medical profession and is primarily used to treat cases of hypogonadism and similar disorders where low androgen levels are at fault.
As with all testosterone products it has strong anabolic and androgenic activity. Gains in strength and muscle mass are notable, along with an increase in libido. It has also been noted that a relief in tendon pain and an increase in stamina are direct effects of testosterone administration. This is probably due to increased water retention coupled with an increase in red blood cells – leading to a greater oxygen uptake in the blood.

On the downside, all the usual androgenic side effects can be expected e.g. oily skin, acne, aggressiveness, facial/body hair growth and male pattern baldness. In addition, testestosterone does have a high tendency to convert into estrogen (related side effects being water retention, storage of excess body fat and possible gynecomastia (the development of breast like tissue in males). This can be greatly reduced by adding a drug such as Nolvadex (or, if your budget can stretch to it, the superior Arimidex). However, the use of anti-estrogens during a cycle of testosterone is thought by some to reduce the anabolic effects of the drug, so you may wish to see whether their use is absolutely necessary before using them. You may also choose to add them towards the end of your cycle rather than throwing them into the mix early and risking slightly lower gains.
If you do begin to experience a little puffines in the nipple area, swelling or soreness you should act immediately to treat it by either adding an anti-estrogen or switching to another compound as your main drug.

Although this drug does have a long active life, most athletes choose to inject it on a weekly basis with the dosage ranging from 250mg- 750mg. This is done in an attempt to keep drug levels at a more uniform level throughout the cycle. Just remember, the higher the dose the more likely estrogenic side effects are to develop – so start out low to asses your tolerance.

STACKING TIPS: Those looking for greater bulk could add an oral like Anadrol 50 or Dianabol.

For more quality and definition an injectable like DecaDurabolin or Equipoise may be a better way to go. In this case you can lower the intake of Enanthate in order to keep estrogen build up to a minimum.

USER FEEDBACK: Those who have used this drug find it produces significant weight and strength gains with side effects well within the tolerable range provided dosages are kept at acceptable levels. Greater stamina and an overall feeling of well being have also been widely reported.

Leigh Penman, in addition to be a staff writer at MuscleSport Mag, has been writing for bodybuilding magazines, websites and nutritional supplement companies since 1985. Whilst residing in the UK, she earned the reputation of being one of the top female writers in bodybuilding-related media. Her credits included being a contributing editor on all the magazines in production as well as filling the shoes of Ladies Editor and Showbiz Editor on two publications (the later being on Arnold’s sanctioned magazine, ‘Bodypower’). During this time she also competed successfully on four occasions (placing in the top four in all contests).

Leigh has been working out for close to thirty years so she is clearly a writer who ‘walks her talk.’
She can be contacted personally at zeal2heal@yahoo.com or you can also check her out at New York’s favorite metaphysical store www.stickstoneandbone.com.